Urinary CD80 Excretion Increases in Idiopathic Minimal-Change Disease

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Urinary CD80 excretion increases in idiopathic minimal-change disease.

CD80 is expressed on all antigen-presenting cells and is present on podocytes in a number of experimental models of nephrotic syndrome. We tested whether urinary soluble CD80 increased with idiopathic minimal-change disease (MCD). We collected urine and serum samples from patients with MCD in relapse and in remission, patients with nephrotic syndrome resulting from other glomerular diseases (FS...

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Minimal Change Disease.

Minimal change disease (MCD) is a major cause of idiopathic nephrotic syndrome (NS), characterized by intense proteinuria leading to edema and intravascular volume depletion. In adults, it accounts for approximately 15% of patients with idiopathic NS, reaching a much higher percentage at younger ages, up to 70%-90% in children >1 year of age. In the pediatric setting, a renal biopsy is usually ...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2008

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.2007080836